Getting Started with immunogenetr

Overview

immunogenetr is a comprehensive toolkit for clinical HLA informatics, built on tidyverse principles. It uses the genotype list string (GL string, https://glstring.org/) as its core data structure for storing and computing HLA genotype data.

This vignette walks through the main workflows:

Converting tabular HLA data to GL strings
Splitting GL strings back into individual loci
Calculating mismatches between recipient and donor
Summarizing HLA matching for transplantation
Working with HLA allele names (truncation, prefixes, regex)
Reading HML files

Setup

library(immunogenetr)
library(dplyr)

Converting tabular HLA data to GL strings

Clinical HLA data is typically stored in a tabular format, with each allele in its own column. immunogenetr includes the HLA_typing_1 dataset as an example:

# HLA_typing_1 contains typing for 10 individuals across all classical HLA loci.
head(HLA_typing_1, 3)

patient	A1	A2	C1	C2	B1	B2	DRB345_1	DRB345_2	DRB1_1	DRB1_2	DQA1_1	DQA1_2	DQB1_1	DQB1_2	DPA1_1	DPA1_2	DPB1_1	DPB1_2
1	A*24:02	A*29:02	C*07:04	C*16:01	B*44:02	B*44:03	DRB5*01:01	DRB5*01:01	DRB1*15:01	DRB1*15:01	DQA1*01:02	DQA1*01:02	DQB1*06:02	DQB1*06:02	DPA1*01:03	DPA1*01:03	DPB1*03:01	DPB1*04:01
2	A*02:01	A*11:05	C*07:01	C*07:02	B*07:02	B*08:01	DRB3*01:01	DRB4*01:03	DRB1*03:01	DRB1*04:01	DQA1*03:03	DQA1*05:01	DQB1*02:01	DQB1*03:01	DPA1*01:03	DPA1*01:03	DPB1*04:01	DPB1*04:01
3	A*02:01	A*26:18	C*02:02	C*03:04	B*27:05	B*54:01	DRB3*02:02	DRB4*01:03	DRB1*04:04	DRB1*14:54	DQA1*01:04	DQA1*03:01	DQB1*03:02	DQB1*05:02	DPA1*01:03	DPA1*02:02	DPB1*02:01	DPB1*05:01

The HLA_columns_to_GLstring() function converts these columns into a single GL string per individual. When used inside mutate(), pass . as the first argument to reference the working data frame:

HLA_typing_GL <- HLA_typing_1 %>%
  # Convert all typing columns (A1 through DPB1_2) into a GL string.
  mutate(
    GL_string = HLA_columns_to_GLstring(., HLA_typing_columns = A1:DPB1_2),
    .after = patient
  ) %>%
  # Keep only patient ID and the new GL string column.
  select(patient, GL_string)

# View the GL strings.
(HLA_typing_GL)

patient	GL_string
1	HLA-A24:02+HLA-A29:02^HLA-C07:04+HLA-C16:01^HLA-B44:02+HLA-B44:03^HLA-DRB501:01+HLA-DRB501:01^HLA-DRB115:01+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA101:02^HLA-DQB106:02+HLA-DQB106:02^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB103:01+HLA-DPB104:01
2	HLA-A02:01+HLA-A11:05^HLA-C07:01+HLA-C07:02^HLA-B07:02+HLA-B08:01^HLA-DRB301:01^HLA-DRB401:03^HLA-DRB103:01+HLA-DRB104:01^HLA-DQA103:03+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB103:01^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB104:01+HLA-DPB104:01
3	HLA-A02:01+HLA-A26:18^HLA-C02:02+HLA-C03:04^HLA-B27:05+HLA-B54:01^HLA-DRB302:02^HLA-DRB401:03^HLA-DRB104:04+HLA-DRB114:54^HLA-DQA101:04+HLA-DQA103:01^HLA-DQB103:02+HLA-DQB105:02^HLA-DPA101:03+HLA-DPA102:02^HLA-DPB102:01+HLA-DPB105:01
4	HLA-A29:02+HLA-A30:02^HLA-C06:02+HLA-C07:01^HLA-B08:01+HLA-B13:02^HLA-DRB401:03+HLA-DRB401:03^HLA-DRB104:01+HLA-DRB107:01^HLA-DQA102:01+HLA-DQA103:01^HLA-DQB102:02+HLA-DQB103:02^HLA-DPA101:03+HLA-DPA102:01^HLA-DPB101:01+HLA-DPB116:01
5	HLA-A02:05+HLA-A24:02^HLA-C07:18+HLA-C12:03^HLA-B35:03+HLA-B58:01^HLA-DRB302:02+HLA-DRB302:02^HLA-DRB103:01+HLA-DRB114:54^HLA-DQA101:04+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB105:03^HLA-DPA101:03+HLA-DPA102:01^HLA-DPB110:01+HLA-DPB1124:01
6	HLA-A01:01+HLA-A24:02^HLA-C07:01+HLA-C14:02^HLA-B49:01+HLA-B51:01^HLA-DRB303:01^HLA-DRB108:01+HLA-DRB113:02^HLA-DQA101:02+HLA-DQA104:01^HLA-DQB104:02+HLA-DQB106:04^HLA-DPA101:03+HLA-DPA101:04^HLA-DPB104:01+HLA-DPB1*15:01
7	HLA-A03:01+HLA-A03:01^HLA-C03:03+HLA-C16:01^HLA-B15:01+HLA-B51:01^HLA-DRB401:01^HLA-DRB101:01+HLA-DRB107:01^HLA-DQA101:01+HLA-DQA102:01^HLA-DQB102:02+HLA-DQB105:01^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB104:01+HLA-DPB1*04:01
8	HLA-A01:01+HLA-A32:01^HLA-C06:02+HLA-C07:02^HLA-B08:01+HLA-B37:01^HLA-DRB302:02^HLA-DRB501:01^HLA-DRB103:01+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB106:02^HLA-DPA101:03+HLA-DPA102:01^HLA-DPB104:01+HLA-DPB114:01
9	HLA-A03:01+HLA-A30:01^HLA-C07:02+HLA-C12:03^HLA-B07:02+HLA-B38:01^HLA-DRB301:01^HLA-DRB501:01^HLA-DRB103:01+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB106:02^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB104:01+HLA-DPB104:01
10	HLA-A02:05+HLA-A11:01^HLA-C07:18+HLA-C16:02^HLA-B51:01+HLA-B58:01^HLA-DRB303:01^HLA-DRB501:01^HLA-DRB113:02+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA101:03^HLA-DQB106:01+HLA-DQB106:09^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB102:01+HLA-DPB1104:01

Each GL string encodes the full genotype: alleles within a gene copy are separated by / (ambiguity), gene copies by +, and loci by ^.

Splitting GL strings into loci

To go the other direction, GLstring_genes() splits a GL string back into separate columns by locus:

# Take the first patient's GL string and split it into locus columns.
# Note: GLstring_genes and GLstring_genes_expanded use pivot_longer on all
# columns, so only pass the GL string column (no other data types).
single_patient <- HLA_typing_GL[1, "GL_string", drop = FALSE]
GLstring_genes(single_patient, "GL_string")

HLA_A	HLA_C	HLA_B	HLA_DRB5	HLA_DRB1	HLA_DQA1	HLA_DQB1	HLA_DPA1	HLA_DPB1
HLA-A24:02+HLA-A29:02	HLA-C07:04+HLA-C16:01	HLA-B44:02+HLA-B44:03	HLA-DRB501:01+HLA-DRB501:01	HLA-DRB115:01+HLA-DRB115:01	HLA-DQA101:02+HLA-DQA101:02	HLA-DQB106:02+HLA-DQB106:02	HLA-DPA101:03+HLA-DPA101:03	HLA-DPB103:01+HLA-DPB104:01

For a fully expanded view with one allele per row, use GLstring_genes_expanded():

GLstring_genes_expanded(single_patient, "GL_string")

A	C	B	DRB5	DRB1	DQA1	DQB1	DPA1	DPB1
HLA-A*24:02	HLA-C*07:04	HLA-B*44:02	HLA-DRB5*01:01	HLA-DRB1*15:01	HLA-DQA1*01:02	HLA-DQB1*06:02	HLA-DPA1*01:03	HLA-DPB1*03:01
HLA-A*29:02	HLA-C*16:01	HLA-B*44:03	HLA-DRB5*01:01	HLA-DRB1*15:01	HLA-DQA1*01:02	HLA-DQB1*06:02	HLA-DPA1*01:03	HLA-DPB1*04:01

Calculating HLA mismatches

The mismatch functions are the core of immunogenetr. They all take a recipient GL string, a donor GL string, one or more loci, and a direction.

Let’s set up a recipient/donor pair:

# Patient 7 is the recipient, patient 9 is the donor.
recip_gl <- HLA_typing_GL %>% filter(patient == 7) %>% pull(GL_string)
donor_gl <- HLA_typing_GL %>% filter(patient == 9) %>% pull(GL_string)

Is there a mismatch? (`HLA_mismatch_logical`)

# Check if there is an HLA-A mismatch in the graft-vs-host direction.
HLA_mismatch_logical(recip_gl, donor_gl, "HLA-A", direction = "GvH")

#> [1] FALSE

# Check host-vs-graft direction.
HLA_mismatch_logical(recip_gl, donor_gl, "HLA-A", direction = "HvG")

#> [1] TRUE

How many mismatches? (`HLA_mismatch_number`)

# Count bidirectional mismatches across several loci at once.
HLA_mismatch_number(
  recip_gl, donor_gl,
  c("HLA-A", "HLA-B", "HLA-C", "HLA-DRB1"),
  direction = "bidirectional"
)

#> [1] "HLA-A=1, HLA-B=2, HLA-C=2, HLA-DRB1=2"

Which alleles are mismatched? (`HLA_mismatched_alleles`)

# Identify the specific mismatched alleles in the HvG direction.
HLA_mismatched_alleles(recip_gl, donor_gl, "HLA-A", direction = "HvG")

#> [1] "HLA-A*30:01"

Match count (`HLA_match_number`)

# Count the number of matches (complement of mismatches).
HLA_match_number(
  recip_gl, donor_gl,
  c("HLA-A", "HLA-B", "HLA-C", "HLA-DRB1"),
  direction = "bidirectional"
)

#> [1] "HLA-A=1, HLA-B=0, HLA-C=0, HLA-DRB1=0"

HLA match summaries for transplantation

The HLA_match_summary_HCT() function provides standard match grades used in hematopoietic cell transplantation:

# X-of-8 matching (A, B, C, DRB1 bidirectional).
HLA_match_summary_HCT(recip_gl, donor_gl,
  direction = "bidirectional",
  match_grade = "Xof8"
)

#> [1] 1

# X-of-10 matching (adds DQB1).
HLA_match_summary_HCT(recip_gl, donor_gl,
  direction = "bidirectional",
  match_grade = "Xof10"
)

#> [1] 1

Finding the best donor

A common workflow is comparing one recipient against multiple potential donors:

# Patient 3 is the recipient; compare against all 10 donors.
recipient <- HLA_typing_GL %>%
  filter(patient == 3) %>%
  select(GL_string) %>%
  rename(GL_string_recip = GL_string)

donors <- HLA_typing_GL %>%
  rename(GL_string_donor = GL_string, donor = patient) %>%
  # Cross-join to pair recipient with each donor.
  cross_join(recipient) %>%
  # Calculate 8/8 match grade for each pair.
  mutate(
    match_8of8 = HLA_match_summary_HCT(
      GL_string_recip, GL_string_donor,
      direction = "bidirectional",
      match_grade = "Xof8"
    ),
    .after = donor
  ) %>%
  # Sort best matches first.
  arrange(desc(match_8of8))

donors %>% select(donor, match_8of8)

donor	match_8of8
3	8
2	1
5	1
1	0
4	0
6	0
7	0
8	0
9	0
10	0

Working with HLA allele names

Truncation

HLA_truncate() reduces allele resolution to a specified number of fields:

# Truncate a four-field allele to two fields.
HLA_truncate("HLA-A*02:01:01:01", fields = 2)

#> [1] "HLA-A*02:01"

# Works on full GL strings too.
HLA_truncate("HLA-A*02:01:01:01+HLA-A*03:01:01:02^HLA-B*07:02:01:01+HLA-B*44:02:01:01",
  fields = 2
)

#> [1] "HLA-A*02:01+HLA-A*03:01^HLA-B*07:02+HLA-B*44:02"

Prefix management

HLA_prefix_remove() and HLA_prefix_add() manage the HLA- and locus prefixes:

# Remove all prefixes to get just the allele fields.
HLA_prefix_remove("HLA-A*02:01")

#> [1] "02:01"

# Keep the locus designation but remove "HLA-".
HLA_prefix_remove("HLA-A*02:01", keep_locus = TRUE)

#> [1] "A*02:01"

# Add the full prefix back.
HLA_prefix_add("02:01", "HLA-A*")

#> [1] "HLA-A*02:01"

# "HLA-" is added by default.
HLA_prefix_add("A*02:01")

#> [1] "HLA-A*02:01"

Regex for GL string searching

GLstring_regex() creates regex patterns that accurately search within GL strings, preventing partial matches across field boundaries:

gl <- "HLA-A*02:01:01+HLA-A*68:01^HLA-B*07:01+HLA-B*15:01"

# A two-field search correctly matches the three-field allele.
pattern <- GLstring_regex("HLA-A*02:01")
stringr::str_detect(gl, pattern)

#> [1] TRUE

# But won't falsely match a longer allele number.
stringr::str_detect("HLA-A*02:149:01", GLstring_regex("HLA-A*02:14"))

#> [1] FALSE

Column name repair

When working in the tidyverse, column names with dashes and asterisks are inconvenient. HLA_column_repair() converts between WHO-standard (HLA-A*) and tidyverse-friendly (HLA_A) formats:

# GLstring_genes returns tidyverse-friendly names by default.
repaired <- GLstring_genes(single_patient, "GL_string")
names(repaired)

#> [1] "HLA_A"    "HLA_C"    "HLA_B"    "HLA_DRB5" "HLA_DRB1" "HLA_DQA1" "HLA_DQB1"
#> [8] "HLA_DPA1" "HLA_DPB1"

# Convert back to WHO format with asterisks.
who_names <- HLA_column_repair(repaired, format = "WHO", asterisk = TRUE)
names(who_names)

#> [1] "HLA-A*"    "HLA-C*"    "HLA-B*"    "HLA-DRB5*" "HLA-DRB1*" "HLA-DQA1*"
#> [7] "HLA-DQB1*" "HLA-DPA1*" "HLA-DPB1*"

Reading HML files

The read_HML() function extracts GL strings from HML (HLA Markup Language) files, which are a standard format for reporting HLA typing results from next-generation sequencing:

# immunogenetr ships with two example HML files.
hml_path <- system.file("extdata", "HML_1.hml", package = "immunogenetr")
hml_result <- read_HML(hml_path)
hml_result

sampleID	GL_string
22-03848-HLA-031722-AB-AlloSeq-EP	HLA-A33:03:01:01+HLA-A34:02:01:01^HLA-B14:01:01:01+HLA-B44:03:02:04^HLA-C07:06:01:01/HLA-C07:06:01:02/HLA-C07:06:01:03/HLA-C07:06:01:04/HLA-C07:06:01:07/HLA-C07:06:01:08/HLA-C07:06:01:09/HLA-C07:06:01:10/HLA-C07:06:01:11/HLA-C07:06:01:12/HLA-C07:06:01:06+HLA-C08:02:01:02^HLA-G01:01:09+HLA-G01:04:01:01^HLA-E01:01:01:01+HLA-E01:03:01:11^HLA-F01:01:02:10+HLA-F01:02:01:02^HLA-DRB108:04:01:01/HLA-DRB108:04:01:02/HLA-DRB108:04:01:03/HLA-DRB108:04:01:04/HLA-DRB108:04:01:05+HLA-DRB113:02:01:01/HLA-DRB113:02:01:03/HLA-DRB113:02:01:04/HLA-DRB113:02:01:06/HLA-DRB113:02:01:10/HLA-DRB113:02:01:14^HLA-DRB303:01:01:01/HLA-DRB303:01:01:02/HLA-DRB303:01:01:03/HLA-DRB303:01:07/HLA-DRB303:37/HLA-DRB303:44/HLA-DRB303:49+HLA-DRB303:01:01:01/HLA-DRB303:01:01:02/HLA-DRB303:01:01:03/HLA-DRB303:01:07/HLA-DRB303:37/HLA-DRB303:44/HLA-DRB303:49^HLA-DQB103:19:01:01+HLA-DQB106:09:01:01^HLA-DQA101:02:01:04+HLA-DQA104:01:02:01/HLA-DQA104:01:02:02^HLA-DPB1104:01:01:01/HLA-DPB1104:01:01:02/HLA-DPB1104:01:01:03/HLA-DPB1104:01:01:04/HLA-DPB1104:01:01:05/HLA-DPB1104:01:01:06/HLA-DPB1104:01:01:07/HLA-DPB1104:01:01:08/HLA-DPB1104:01:01:09/HLA-DPB1104:01:01:10/HLA-DPB1104:01:01:11/HLA-DPB1104:01:01:12/HLA-DPB1104:01:01:14+HLA-DPB1584:01:02:01/HLA-DPB1584:01:02:02^HLA-DPA101:03:01:02/HLA-DPA101:03:01:30/HLA-DPA101:03:01:34/HLA-DPA101:03:01:76/HLA-DPA101:03:01:78+HLA-DPA103:05:01:01Q/HLA-DPA103:05:01:02Q^HLA-H02:08:01:01+HLA-H02:11:01:01^MICA004:01:01/MICA004:01:09/MICA004:01:10/MICA004:01:11/MICA004:01:02/MICA004:01:04/MICA004:01:05/MICA004:01:03/MICA004:01:06/MICA004:01:07/MICA004:01:08/MICA004:01:12/MICA004:01:13+MICA008:04:01/MICA008:04:04/MICA008:04:06^MICB002:01:18/MICB002:01:19/MICB002:01:20/MICB002:01:23/MICB002:01:26/MICB002:01:27+MICB005:02:05/MICB005:02:19/MICB*005:02:27
22-03849-HLA-031722-AB-AlloSeq-EP	HLA-A23:01:01:01+HLA-A30:01:01:01^HLA-B53:01:01:01+HLA-B81:01:01:01^HLA-C06:02:01:01/HLA-C06:02:01:72/HLA-C06:02:01:03/HLA-C06:02:01:05/HLA-C06:02:01:06/HLA-C06:02:01:08/HLA-C06:02:01:10/HLA-C06:02:01:11/HLA-C06:02:01:12/HLA-C06:02:01:13/HLA-C06:02:01:18/HLA-C06:02:01:21/HLA-C06:02:01:24/HLA-C06:02:01:25/HLA-C06:02:01:26/HLA-C06:02:01:27/HLA-C06:02:01:28/HLA-C06:02:01:29/HLA-C06:02:01:30/HLA-C06:02:01:31/HLA-C06:02:01:32/HLA-C06:02:01:34/HLA-C06:02:01:35/HLA-C06:02:01:36/HLA-C06:02:01:37/HLA-C06:02:01:38/HLA-C06:02:01:39/HLA-C06:02:01:44/HLA-C06:02:01:45/HLA-C06:02:01:48/HLA-C06:02:01:49/HLA-C06:02:01:51/HLA-C06:02:01:52/HLA-C06:02:01:54/HLA-C06:02:01:55/HLA-C06:02:01:56/HLA-C06:02:01:57/HLA-C06:02:01:58/HLA-C06:02:01:61/HLA-C06:02:01:62/HLA-C06:02:01:63/HLA-C06:02:01:65/HLA-C06:02:01:67/HLA-C06:02:01:68/HLA-C06:02:01:69/HLA-C06:02:01:73/HLA-C06:02:01:76/HLA-C06:02:01:77/HLA-C06:02:01:78/HLA-C06:02:01:81/HLA-C06:02:01:82/HLA-C06:02:01:83/HLA-C06:02:01:84/HLA-C06:02:01:85/HLA-C06:02:01:86/HLA-C06:02:01:88/HLA-C06:02:01:89/HLA-C06:02:01:90/HLA-C06:02:01:91/HLA-C06:02:01:92/HLA-C06:02:01:93/HLA-C06:02:01:94/HLA-C06:02:01:95/HLA-C06:02:01:96/HLA-C06:02:01:02/HLA-C06:02:01:04/HLA-C06:02:01:07/HLA-C06:02:01:09/HLA-C06:02:01:14/HLA-C06:02:01:16/HLA-C06:02:01:17/HLA-C06:02:01:19/HLA-C06:02:01:20/HLA-C06:02:01:22/HLA-C06:02:01:41/HLA-C06:02:01:42/HLA-C06:02:01:46/HLA-C06:02:01:47/HLA-C06:02:01:50/HLA-C06:02:01:53/HLA-C06:02:01:64/HLA-C06:02:01:66/HLA-C06:02:01:70/HLA-C06:02:01:71/HLA-C06:02:01:74/HLA-C06:02:01:75/HLA-C06:02:01:79/HLA-C06:02:01:80/HLA-C06:02:01:87/HLA-C06:02:01:97/HLA-C06:02:01:23/HLA-C06:02:01:59/HLA-C06:02:01:40/HLA-C06:02:01:60/HLA-C06:02:01:33/HLA-C06:02:01:15/HLA-C06:02:01:43+HLA-C08:04:01:01/HLA-C08:04:01:02/HLA-C08:04:01:03^HLA-G01:04:04:01+HLA-G01:05:01N^HLA-E01:01:01:01+HLA-E01:01:01:01^HLA-F01:01:01:09/HLA-F01:01:01:10/HLA-F01:01:01:11/HLA-F01:01:01:12/HLA-F01:01:01:27/HLA-F01:01:01:29/HLA-F01:01:01:42/HLA-F01:01:01:43/HLA-F01:01:01:07/HLA-F01:01:01:28/HLA-F01:01:01:36/HLA-F01:01:01:05/HLA-F01:01:01:03/HLA-F01:01:01:04/HLA-F01:01:01:16/HLA-F01:01:01:14/HLA-F01:01:01:18/HLA-F01:01:01:06/HLA-F01:01:01:17/HLA-F01:01:01:23/HLA-F01:01:01:24/HLA-F01:01:01:13/HLA-F01:01:01:22/HLA-F01:01:01:39/HLA-F01:01:01:01/HLA-F01:01:01:08/HLA-F01:01:01:02/HLA-F01:01:01:15/HLA-F01:01:01:19/HLA-F01:01:01:20/HLA-F01:01:01:21/HLA-F01:01:01:25/HLA-F01:01:01:26/HLA-F01:01:01:30/HLA-F01:01:01:31/HLA-F01:01:01:32/HLA-F01:01:01:33/HLA-F01:01:01:34/HLA-F01:01:01:35/HLA-F01:01:01:37/HLA-F01:01:01:38/HLA-F01:01:01:40/HLA-F01:01:01:41+HLA-F01:03:01:03^HLA-DRB112:01:01:01/HLA-DRB112:01:01:02/HLA-DRB112:01:01:03/HLA-DRB112:01:01:04/HLA-DRB112:01:01:05/HLA-DRB112:01:01:06/HLA-DRB112:01:01:07/HLA-DRB112:01:01:08/HLA-DRB112:01:01:09/HLA-DRB112:01:01:10/HLA-DRB112:01:01:11/HLA-DRB112:01:01:12/HLA-DRB112:01:01:13/HLA-DRB112:01:01:14+HLA-DRB113:04^HLA-DRB301:01:02:04/HLA-DRB301:01:02:01/HLA-DRB301:01:02:02/HLA-DRB301:01:02:03/HLA-DRB301:01:02:05/HLA-DRB301:01:02:06/HLA-DRB301:86/HLA-DRB301:114/HLA-DRB301:119+HLA-DRB302:02:01:01/HLA-DRB302:02:01:12/HLA-DRB302:02:23/HLA-DRB302:02:26/HLA-DRB302:02:30/HLA-DRB302:02:31/HLA-DRB302:96/HLA-DRB302:144/HLA-DRB302:151/HLA-DRB302:161/HLA-DRB302:167/HLA-DRB302:168/HLA-DRB302:176/HLA-DRB302:178/HLA-DRB302:183/HLA-DRB302:185/HLA-DRB302:186/HLA-DRB302:191^HLA-DQB103:19:01:01+HLA-DQB105:01:01:02/HLA-DQB105:01:01:19^HLA-DQA101:05:01:01+HLA-DQA105:05:01:13/HLA-DQA105:05:01:16/HLA-DQA105:05:01:17/HLA-DQA105:05:01:19/HLA-DQA105:05:01:24/HLA-DQA105:05:01:27/HLA-DQA105:05:01:29/HLA-DQA105:05:01:30/HLA-DQA105:05:01:35/HLA-DQA105:05:01:36/HLA-DQA105:05:01:01/HLA-DQA105:05:01:02/HLA-DQA105:05:01:04/HLA-DQA105:05:01:07/HLA-DQA105:05:01:08/HLA-DQA105:05:01:09/HLA-DQA105:05:01:11/HLA-DQA105:05:01:21/HLA-DQA105:05:01:26/HLA-DQA105:05:01:28/HLA-DQA105:05:01:32/HLA-DQA105:05:01:39/HLA-DQA105:05:01:03/HLA-DQA105:05:01:05/HLA-DQA105:05:01:06/HLA-DQA105:05:01:10/HLA-DQA105:05:01:12/HLA-DQA105:05:01:14/HLA-DQA105:05:01:15/HLA-DQA105:05:01:18/HLA-DQA105:05:01:20/HLA-DQA105:05:01:22/HLA-DQA105:05:01:23/HLA-DQA105:05:01:25/HLA-DQA105:05:01:31/HLA-DQA105:05:01:33/HLA-DQA105:05:01:34/HLA-DQA105:05:01:37/HLA-DQA105:05:01:40/HLA-DQA105:05:01:38^HLA-DPB102:01:02:02/HLA-DPB102:01:02:08/HLA-DPB102:01:02:09/HLA-DPB102:01:02:16/HLA-DPB102:01:02:18/HLA-DPB102:01:02:19/HLA-DPB102:01:02:56/HLA-DPB102:01:02:84+HLA-DPB1105:01:01:01/HLA-DPB1105:01:01:02/HLA-DPB1105:01:01:03/HLA-DPB1105:01:01:04/HLA-DPB1105:01:01:06/HLA-DPB1105:01:01:09/HLA-DPB1105:01:01:11/HLA-DPB1105:01:01:12/HLA-DPB1105:01:01:13/HLA-DPB1105:01:01:15/HLA-DPB1105:01:01:16/HLA-DPB1105:01:01:18^HLA-DPA101:03:01:31+HLA-DPA103:01:01:09^HLA-H02:05:01:03+HLA-H02:05:01:03^MICA008:04:03+MICA018:01:01/MICA018:01:03/MICA018:01:08/MICA018:01:12^MICB002:01:01/MICB002:01:02/MICB002:01:03/MICB002:01:04/MICB002:01:05/MICB002:01:06/MICB002:01:07/MICB002:01:09/MICB002:01:10/MICB002:01:15/MICB002:01:16/MICB002:01:21/MICB002:01:22/MICB002:01:11/MICB002:01:12/MICB002:01:13/MICB002:01:14/MICB002:01:28/MICB002:01:18/MICB002:01:19/MICB002:01:20/MICB002:01:23/MICB002:01:26/MICB002:01:27/MICB002:01:08/MICB002:01:17/MICB002:01:24/MICB002:01:25+MICB005:02:05/MICB005:02:19/MICB005:02:27
22-03850-HLA-031722-AB-AlloSeq-EP	HLA-A02:01:01:01+HLA-A02:01:01:01^HLA-B35:01:01:06+HLA-B39:10:01^HLA-C04:01:01:14+HLA-C12:03:01:01^HLA-G01:01:01:01+HLA-G01:01:01:01^HLA-E01:01:01:01+HLA-E01:01:01:01^HLA-F01:01:01:01+HLA-F01:01:01:17^HLA-DRB107:01:01:01/HLA-DRB107:01:01:02/HLA-DRB107:01:01:04/HLA-DRB107:01:01:05/HLA-DRB107:01:01:06/HLA-DRB107:01:01:07/HLA-DRB107:01:01:08/HLA-DRB107:01:01:09/HLA-DRB107:01:01:10/HLA-DRB107:01:01:11/HLA-DRB107:01:01:12/HLA-DRB107:01:01:13/HLA-DRB107:01:01:14/HLA-DRB107:01:01:15/HLA-DRB107:01:01:16/HLA-DRB107:01:01:17/HLA-DRB107:01:01:18/HLA-DRB107:01:01:19/HLA-DRB107:01:01:20/HLA-DRB107:01:01:22/HLA-DRB107:01:01:23/HLA-DRB107:01:01:24/HLA-DRB107:01:01:25/HLA-DRB107:01:01:26/HLA-DRB107:01:01:27/HLA-DRB107:01:01:28/HLA-DRB107:01:01:29+HLA-DRB115:03:01:01/HLA-DRB115:03:01:02/HLA-DRB115:03:01:03/HLA-DRB115:03:01:04^HLA-DRB401:03:01:01/HLA-DRB401:03:01:03/HLA-DRB401:03:01:04/HLA-DRB401:03:01:10/HLA-DRB401:03:01:11/HLA-DRB401:03:01:14/HLA-DRB401:03:01:15/HLA-DRB401:03:01:16/HLA-DRB401:03:01:17/HLA-DRB401:03:01:18/HLA-DRB401:03:01:09/HLA-DRB401:03:01:05/HLA-DRB401:03:01:06/HLA-DRB401:03:01:07/HLA-DRB401:03:01:08/HLA-DRB401:03:01:12+HLA-DRB401:03:01:01/HLA-DRB401:03:01:03/HLA-DRB401:03:01:04/HLA-DRB401:03:01:10/HLA-DRB401:03:01:11/HLA-DRB401:03:01:14/HLA-DRB401:03:01:15/HLA-DRB401:03:01:16/HLA-DRB401:03:01:17/HLA-DRB401:03:01:18/HLA-DRB401:03:01:09/HLA-DRB401:03:01:05/HLA-DRB401:03:01:06/HLA-DRB401:03:01:07/HLA-DRB401:03:01:08/HLA-DRB401:03:01:12^HLA-DRB501:01:01:02/HLA-DRB501:01:01:04/HLA-DRB501:01:01:05/HLA-DRB501:01:01:06+HLA-DRB501:01:01:02/HLA-DRB501:01:01:04/HLA-DRB501:01:01:05/HLA-DRB501:01:01:06/HLA-DRB501:01:01:01/HLA-DRB501:01:01:03^HLA-DQB102:02:01:01/HLA-DQB102:02:01:05/HLA-DQB102:02:01:08/HLA-DQB102:02:01:16/HLA-DQB102:02:01:18+HLA-DQB106:02:01:01/HLA-DQB106:02:01:14/HLA-DQB106:02:01:15/HLA-DQB106:02:01:23/HLA-DQB106:02:01:25/HLA-DQB106:02:01:26/HLA-DQB106:02:01:02/HLA-DQB106:02:01:03/HLA-DQB106:02:01:05/HLA-DQB106:02:01:07/HLA-DQB106:02:01:08/HLA-DQB106:02:01:09/HLA-DQB106:02:01:10/HLA-DQB106:02:01:11/HLA-DQB106:02:01:12/HLA-DQB106:02:01:13/HLA-DQB106:02:01:16/HLA-DQB106:02:01:17/HLA-DQB106:02:01:21/HLA-DQB106:02:01:22/HLA-DQB106:02:01:28/HLA-DQB106:02:01:29/HLA-DQB106:02:01:30/HLA-DQB106:02:01:31/HLA-DQB106:02:01:34/HLA-DQB106:02:01:35/HLA-DQB106:02:01:36/HLA-DQB106:02:01:37/HLA-DQB106:02:01:04/HLA-DQB106:02:01:19/HLA-DQB106:02:01:20/HLA-DQB106:02:01:27/HLA-DQB106:02:01:33/HLA-DQB106:02:01:06/HLA-DQB106:02:01:24^HLA-DQA101:02:01:01/HLA-DQA101:02:01:02/HLA-DQA101:02:01:03/HLA-DQA101:02:01:05/HLA-DQA101:02:01:10/HLA-DQA101:02:01:11/HLA-DQA101:02:01:27/HLA-DQA101:02:01:30+HLA-DQA102:01:01:01/HLA-DQA102:01:01:02/HLA-DQA102:01:01:05^HLA-DPB101:01:01:01/HLA-DPB101:01:01:02/HLA-DPB101:01:01:03/HLA-DPB101:01:01:04/HLA-DPB101:01:01:09/HLA-DPB101:01:01:10/HLA-DPB101:01:01:12/HLA-DPB101:01:01:14/HLA-DPB101:01:01:15/HLA-DPB101:01:01:16/HLA-DPB101:01:01:17/HLA-DPB101:01:01:19/HLA-DPB101:01:01:20/HLA-DPB101:01:01:22/HLA-DPB101:01:01:24/HLA-DPB101:01:01:25+HLA-DPB111:01:01:01/HLA-DPB111:01:01:02/HLA-DPB111:01:01:03\|HLA-DPB1417:01:01+HLA-DPB1654:01^HLA-DPA102:01:01:01/HLA-DPA102:01:01:06/HLA-DPA102:01:01:16+HLA-DPA102:02:02:09/HLA-DPA102:02:02:12^HLA-H01:01:01:01+HLA-H01:01:01:01^MICA002:01:01/MICA002:01:11/MICA002:01:03/MICA002:01:05/MICA002:01:07/MICA002:01:08/MICA002:01:14/MICA002:01:15/MICA002:01:02/MICA002:01:04/MICA002:01:06/MICA002:01:09/MICA002:01:10/MICA002:01:12/MICA002:01:16/MICA002:01:13Q+MICA002:01:06^MICB005:02:01/MICB005:02:09/MICB005:02:15/MICB005:02:16/MICB005:02:24/MICB005:02:25/MICB005:02:30/MICB005:02:35/MICB005:02:03/MICB005:02:21/MICB005:02:05/MICB005:02:19/MICB005:02:27/MICB005:02:04/MICB005:02:17/MICB005:02:29/MICB005:02:07/MICB005:02:11/MICB005:02:18/MICB005:02:06/MICB005:02:08/MICB005:02:12/MICB005:02:22/MICB005:02:23/MICB005:02:02/MICB005:02:10/MICB005:02:13/MICB005:02:14/MICB005:02:20/MICB005:02:26/MICB005:02:31/MICB005:02:33/MICB005:02:34/MICB005:02:28/MICB005:02:32+MICB005:02:21/MICB005:02:01/MICB005:02:09/MICB005:02:15/MICB005:02:16/MICB005:02:24/MICB005:02:25/MICB005:02:30/MICB005:02:35/MICB005:02:03/MICB005:02:05/MICB005:02:19/MICB005:02:27/MICB005:02:04/MICB005:02:29/MICB005:02:17/MICB005:02:07/MICB005:02:11/MICB005:02:18/MICB005:02:06/MICB005:02:08/MICB005:02:12/MICB005:02:22/MICB005:02:23/MICB005:02:02/MICB005:02:10/MICB005:02:13/MICB005:02:14/MICB005:02:20/MICB005:02:26/MICB005:02:31/MICB005:02:33/MICB005:02:34/MICB005:02:28/MICB*005:02:32
22-03851-HLA-031722-AB-AlloSeq-EP	HLA-A02:01:01:01+HLA-A23:01:01:01^HLA-B45:01:01:03/HLA-B45:01:01:14/HLA-B45:01:01:01/HLA-B45:01:01:04/HLA-B45:01:01:05/HLA-B45:01:01:06/HLA-B45:01:01:07/HLA-B45:01:01:08/HLA-B45:01:01:10/HLA-B45:01:01:11/HLA-B45:01:01:12/HLA-B45:01:01:13/HLA-B45:01:01:09+HLA-B58:113^HLA-C07:18:01:01/HLA-C07:18:01:02/HLA-C07:18:01:03/HLA-C07:18:01:04/HLA-C07:18:01:05/HLA-C07:18:01:06/HLA-C07:18:01:07/HLA-C07:18:01:08/HLA-C07:18:01:09/HLA-C07:18:01:10/HLA-C07:18:01:11/HLA-C07:18:01:12+HLA-C16:01:01:01^HLA-G01:01:01:01+HLA-G01:04:04:01^HLA-E01:01:01:01+HLA-E01:03:02:01^HLA-F01:01:01:01+HLA-F01:03:01:03^HLA-DRB103:01:01:01/HLA-DRB103:01:01:02/HLA-DRB103:01:01:03/HLA-DRB103:01:01:04/HLA-DRB103:01:01:05/HLA-DRB103:01:01:06/HLA-DRB103:01:01:07/HLA-DRB103:01:01:08/HLA-DRB103:01:01:09/HLA-DRB103:01:01:10/HLA-DRB103:01:01:11/HLA-DRB103:01:01:12/HLA-DRB103:01:01:13/HLA-DRB103:01:01:14/HLA-DRB103:01:01:15/HLA-DRB103:01:01:16/HLA-DRB103:01:01:17/HLA-DRB103:01:01:18/HLA-DRB103:01:01:19/HLA-DRB103:01:01:20/HLA-DRB103:01:01:21/HLA-DRB103:01:01:22/HLA-DRB103:01:01:23/HLA-DRB103:01:01:24/HLA-DRB103:01:01:26/HLA-DRB103:01:01:27/HLA-DRB103:01:31/HLA-DRB103:147+HLA-DRB111:02:01:01/HLA-DRB111:02:01:02/HLA-DRB111:02:01:03/HLA-DRB111:02:01:04/HLA-DRB111:02:01:05^HLA-DRB302:02:01:01/HLA-DRB302:02:01:12/HLA-DRB302:02:23/HLA-DRB302:02:26/HLA-DRB302:02:30/HLA-DRB302:02:31/HLA-DRB302:96/HLA-DRB302:144/HLA-DRB302:151/HLA-DRB302:161/HLA-DRB302:167/HLA-DRB302:168/HLA-DRB302:176/HLA-DRB302:178/HLA-DRB302:183/HLA-DRB302:185/HLA-DRB302:186/HLA-DRB302:191/HLA-DRB302:02:01:15/HLA-DRB302:02:01:03/HLA-DRB302:02:01:10/HLA-DRB302:02:01:11/HLA-DRB302:02:01:13/HLA-DRB302:02:01:14/HLA-DRB302:02:01:02/HLA-DRB302:02:01:04/HLA-DRB302:02:01:05/HLA-DRB302:02:01:06/HLA-DRB302:02:01:07/HLA-DRB302:02:01:08/HLA-DRB302:02:01:09/HLA-DRB302:02:01:16/HLA-DRB302:02:01:17+HLA-DRB302:02:01:15^HLA-DQB102:01:01:01/HLA-DQB102:01:01:11/HLA-DQB102:01:01:12+HLA-DQB103:19:01:01^HLA-DQA105:01:01:01/HLA-DQA105:01:01:03+HLA-DQA105:05:01:13/HLA-DQA105:05:01:16/HLA-DQA105:05:01:17/HLA-DQA105:05:01:19/HLA-DQA105:05:01:24/HLA-DQA105:05:01:27/HLA-DQA105:05:01:29/HLA-DQA105:05:01:30/HLA-DQA105:05:01:35/HLA-DQA105:05:01:36^HLA-DPB101:01:01:01/HLA-DPB101:01:01:02/HLA-DPB101:01:01:03/HLA-DPB101:01:01:04/HLA-DPB101:01:01:09/HLA-DPB101:01:01:10/HLA-DPB101:01:01:12/HLA-DPB101:01:01:14/HLA-DPB101:01:01:15/HLA-DPB101:01:01:16/HLA-DPB101:01:01:17/HLA-DPB101:01:01:19/HLA-DPB101:01:01:20/HLA-DPB101:01:01:22/HLA-DPB101:01:01:24/HLA-DPB101:01:01:25+HLA-DPB102:01:02:03/HLA-DPB102:01:02:26/HLA-DPB102:01:02:28/HLA-DPB102:01:02:47/HLA-DPB102:01:02:50/HLA-DPB102:01:02:86^HLA-DPA101:03:01:01/HLA-DPA101:03:01:11/HLA-DPA101:03:01:19/HLA-DPA101:03:01:33/HLA-DPA101:03:01:35/HLA-DPA101:03:01:36/HLA-DPA101:03:01:45/HLA-DPA101:03:01:72/HLA-DPA101:03:01:77/HLA-DPA101:03:01:79/HLA-DPA101:03:01:81+HLA-DPA102:01:08:01/HLA-DPA102:01:08:03^HLA-H01:01:01:05+HLA-H01:01:01:05^MICA002:01:03/MICA002:01:07/MICA002:01:08/MICA002:01:14/MICA002:01:15+MICA015:01^MICB002:01:28+MICB008:01:01/MICB008:01:02/MICB008:01:03/MICB008:01:04/MICB008:01:05/MICB008:01:06/MICB008:01:07/MICB008:01:08/MICB008:01:09/MICB008:01:10/MICB*008:01:11
22-03852-HLA-031722-AB-AlloSeq-EP	HLA-A33:01:01:01+HLA-A33:03:01:01/HLA-A33:03:01:02/HLA-A33:03:01:03/HLA-A33:03:01:06/HLA-A33:03:01:07/HLA-A33:03:01:08/HLA-A33:03:01:09/HLA-A33:03:01:10/HLA-A33:03:01:11/HLA-A33:03:01:12/HLA-A33:03:01:13/HLA-A33:03:01:14/HLA-A33:03:01:16/HLA-A33:03:01:17/HLA-A33:03:01:18/HLA-A33:03:01:19/HLA-A33:03:01:20/HLA-A33:03:01:23/HLA-A33:03:01:25/HLA-A33:03:01:26/HLA-A33:03:01:22/HLA-A33:03:01:04/HLA-A33:03:01:15^HLA-B14:02:01:01+HLA-B35:01:01:05^HLA-C04:01:01:14+HLA-C08:02:01:01^HLA-G01:03:01:02+HLA-G01:04:01:01^HLA-E01:01:01:01+HLA-E01:01:01:01^HLA-F01:01:02:03/HLA-F01:01:02:02/HLA-F01:01:02:07/HLA-F01:01:02:01/HLA-F01:01:02:08/HLA-F01:01:02:11/HLA-F01:01:02:13/HLA-F01:01:02:12/HLA-F01:01:02:09/HLA-F01:01:02:05/HLA-F01:01:02:06/HLA-F01:01:02:10/HLA-F01:01:02:04/HLA-F01:01:02:14+HLA-F01:01:02:10\|HLA-F01:01:02:05/HLA-F01:01:02:06/HLA-F01:01:02:10/HLA-F01:01:02:04/HLA-F01:01:02:14/HLA-F01:01:02:01/HLA-F01:01:02:03/HLA-F01:01:02:08/HLA-F01:01:02:02/HLA-F01:01:02:07/HLA-F01:01:02:13/HLA-F01:01:02:11/HLA-F01:01:02:12/HLA-F01:01:02:09+HLA-F01:01:02:07^HLA-DRB103:02:01:01/HLA-DRB103:02:01:02+HLA-DRB111:02:01:01/HLA-DRB111:02:01:02/HLA-DRB111:02:01:03/HLA-DRB111:02:01:04/HLA-DRB111:02:01:05^HLA-DRB301:62:01:01/HLA-DRB301:62:01:02+HLA-DRB302:02:01:01/HLA-DRB302:02:01:12/HLA-DRB302:02:23/HLA-DRB302:02:26/HLA-DRB302:02:30/HLA-DRB302:02:31/HLA-DRB302:96/HLA-DRB302:144/HLA-DRB302:151/HLA-DRB302:161/HLA-DRB302:167/HLA-DRB302:168/HLA-DRB302:176/HLA-DRB302:178/HLA-DRB302:183/HLA-DRB302:185/HLA-DRB302:186/HLA-DRB302:191^HLA-DQB103:19:01:01+HLA-DQB104:02:01:08^HLA-DQA104:01:01:04/HLA-DQA104:01:01:05/HLA-DQA104:01:01:11+HLA-DQA105:05:01:13/HLA-DQA105:05:01:16/HLA-DQA105:05:01:17/HLA-DQA105:05:01:19/HLA-DQA105:05:01:24/HLA-DQA105:05:01:27/HLA-DQA105:05:01:29/HLA-DQA105:05:01:30/HLA-DQA105:05:01:35/HLA-DQA105:05:01:36^HLA-DPB101:01:01:01/HLA-DPB101:01:01:02/HLA-DPB101:01:01:03/HLA-DPB101:01:01:04/HLA-DPB101:01:01:09/HLA-DPB101:01:01:10/HLA-DPB101:01:01:12/HLA-DPB101:01:01:14/HLA-DPB101:01:01:15/HLA-DPB101:01:01:16/HLA-DPB101:01:01:17/HLA-DPB101:01:01:19/HLA-DPB101:01:01:20/HLA-DPB101:01:01:22/HLA-DPB101:01:01:24/HLA-DPB101:01:01:25+HLA-DPB101:01:02:01/HLA-DPB101:01:02:02/HLA-DPB101:01:02:03^HLA-DPA102:01:01:02+HLA-DPA102:02:02:12^HLA-H02:08:01:01+HLA-H02:12^MICA011:01:01/MICA011:01:06/MICA011:01:08+MICA110^MICB005:02:05/MICB005:02:19/MICB005:02:27+MICB008:01:01/MICB008:01:02/MICB008:01:03/MICB008:01:04/MICB008:01:05/MICB008:01:06/MICB008:01:07/MICB008:01:08/MICB008:01:09/MICB008:01:10/MICB*008:01:11

Disclaimer

This library is intended for research use. Any application making use of this package in a clinical setting will need to be independently validated according to local regulations.

patient	GL_string
1	HLA-A24:02+HLA-A29:02^HLA-C07:04+HLA-C16:01^HLA-B44:02+HLA-B44:03^HLA-DRB501:01+HLA-DRB501:01^HLA-DRB115:01+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA101:02^HLA-DQB106:02+HLA-DQB106:02^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB103:01+HLA-DPB104:01
2	HLA-A02:01+HLA-A11:05^HLA-C07:01+HLA-C07:02^HLA-B07:02+HLA-B08:01^HLA-DRB301:01^HLA-DRB401:03^HLA-DRB103:01+HLA-DRB104:01^HLA-DQA103:03+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB103:01^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB104:01+HLA-DPB104:01
3	HLA-A02:01+HLA-A26:18^HLA-C02:02+HLA-C03:04^HLA-B27:05+HLA-B54:01^HLA-DRB302:02^HLA-DRB401:03^HLA-DRB104:04+HLA-DRB114:54^HLA-DQA101:04+HLA-DQA103:01^HLA-DQB103:02+HLA-DQB105:02^HLA-DPA101:03+HLA-DPA102:02^HLA-DPB102:01+HLA-DPB105:01
4	HLA-A29:02+HLA-A30:02^HLA-C06:02+HLA-C07:01^HLA-B08:01+HLA-B13:02^HLA-DRB401:03+HLA-DRB401:03^HLA-DRB104:01+HLA-DRB107:01^HLA-DQA102:01+HLA-DQA103:01^HLA-DQB102:02+HLA-DQB103:02^HLA-DPA101:03+HLA-DPA102:01^HLA-DPB101:01+HLA-DPB116:01
5	HLA-A02:05+HLA-A24:02^HLA-C07:18+HLA-C12:03^HLA-B35:03+HLA-B58:01^HLA-DRB302:02+HLA-DRB302:02^HLA-DRB103:01+HLA-DRB114:54^HLA-DQA101:04+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB105:03^HLA-DPA101:03+HLA-DPA102:01^HLA-DPB110:01+HLA-DPB1124:01
6	HLA-A01:01+HLA-A24:02^HLA-C07:01+HLA-C14:02^HLA-B49:01+HLA-B51:01^HLA-DRB303:01^HLA-DRB108:01+HLA-DRB113:02^HLA-DQA101:02+HLA-DQA104:01^HLA-DQB104:02+HLA-DQB106:04^HLA-DPA101:03+HLA-DPA101:04^HLA-DPB104:01+HLA-DPB1*15:01
7	HLA-A03:01+HLA-A03:01^HLA-C03:03+HLA-C16:01^HLA-B15:01+HLA-B51:01^HLA-DRB401:01^HLA-DRB101:01+HLA-DRB107:01^HLA-DQA101:01+HLA-DQA102:01^HLA-DQB102:02+HLA-DQB105:01^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB104:01+HLA-DPB1*04:01
8	HLA-A01:01+HLA-A32:01^HLA-C06:02+HLA-C07:02^HLA-B08:01+HLA-B37:01^HLA-DRB302:02^HLA-DRB501:01^HLA-DRB103:01+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB106:02^HLA-DPA101:03+HLA-DPA102:01^HLA-DPB104:01+HLA-DPB114:01
9	HLA-A03:01+HLA-A30:01^HLA-C07:02+HLA-C12:03^HLA-B07:02+HLA-B38:01^HLA-DRB301:01^HLA-DRB501:01^HLA-DRB103:01+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA105:01^HLA-DQB102:01+HLA-DQB106:02^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB104:01+HLA-DPB104:01
10	HLA-A02:05+HLA-A11:01^HLA-C07:18+HLA-C16:02^HLA-B51:01+HLA-B58:01^HLA-DRB303:01^HLA-DRB501:01^HLA-DRB113:02+HLA-DRB115:01^HLA-DQA101:02+HLA-DQA101:03^HLA-DQB106:01+HLA-DQB106:09^HLA-DPA101:03+HLA-DPA101:03^HLA-DPB102:01+HLA-DPB1104:01